ANIMAL MODELS OF VISCERAL PAIN: CHALLENGES & OPPORTUNITIES
Maeghan Murie, Ehsan Mohammadi, Beverley Greenwood-Van Meerveld.
University of Oklahoma Health Sciences Center, Oklahoma City, OK.
Visceral pain is a hallmark feature in the pathophysiology of functional gastrointestinal disorders such as irritable bowel syndrome (IBS). Although IBS accounts for nearly $30 billion spent on health care per year, it remains a poorly treated condition due to a lack of understanding of the mechanisms behind visceral pain. Experimental models provide a pathway to gain a better understanding of the mechanisms underlying visceral pain and will play a pivotal role in the development of new treatments for patients with visceral pain. This presentation will provide 1) a brief overview of existing animal models of visceral pain, 2) outline what we have learned from these models, and 3) discuss the challenges and opportunities associated with using these models to develop novel therapeutic approaches to treat visceral pain.