SYNTHESIS OF NOVEL NON-INNOCENT LIGANDS FOR METAL-CATALYZED HYDROFORMYLATION
David Delgadillo1, Ramiro Barraza, Ryan Baxter.
University of California, Merced, Merced, CA.
Many pharmaceuticals such as salicylic acid acetate, aspirin, are composed of esters, aldehydes, and carboxylic acids. Hydroformylation is one of the processes used to synthesize these organic functional groups; which encompasses the addition of a formyl group and a hydrogen atom to a carbon-carbon double bond. The biggest concern with the current formylation process is that the catalysts are either inefficient or are very expensive. In this presentation, we will discuss our work on a variety of symmetrical and asymmetrical non-innocent ligands. These non-innocent ligands have been shown to be redox active, which allow the ligands to participate in the catalytic cycle. With that being the case, we are investigating these non-innocent ligands and their potentiality as catalysts for optimizing mechanistic selectivity in asymmetric hydroformylation. It is significant to research non-innocent ligands because they offer novel catalyst alternatives that are efficient and inexpensive. Producing more efficient and affordable catalysts for the hydroformylation would reduce the use of precious metals such as rhodium and improve the availability of organic functional groups by expanding catalytic resources.